BDBM10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1
SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
InChI Key InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 10880
Affinity DataKi: 3.10nMAssay Description:Inhibition of human carbonic anhydrase 3More data for this Ligand-Target Pair
Affinity DataKi: 240nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
Affinity DataKi: 254nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
Affinity DataKi: 437nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
Affinity DataKi: 510nMpH: 7.5Assay Description:Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human CA3 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 3 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human CAH3 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase3 cytosolic isoform expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Inhibition of human CA3 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Inhibition of human CA3 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 3 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of carbonic anhydrase-3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 8.34E+4nMAssay Description:Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 3 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human recombinant CA3 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human carbonic anhydrase-3 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human recombinant full length CA3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human CA3 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human full length carbonic anhydrase 3 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 3 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nM ΔG°: -5.01kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nM ΔG°: -5.04kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nM ΔG°: -5.04kcal/molepH: 7.4 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 2.36E+5nMAssay Description:Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+5nMAssay Description:Inhibition of human CA3 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+5nMAssay Description:Inhibition of human carbonic anhydrase 3 after 15 mins by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 using carbon-dioxide as substrate preincubated for 10 mins prior to substrate addition by stoppe...More data for this Ligand-Target Pair
Affinity DataKi: 2.63E+5nMpH: 7.4Assay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
Affinity DataKi: 2.63E+5nMpH: 7.4Assay Description:The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s...More data for this Ligand-Target Pair
Affinity DataKi: 2.63E+5nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a spect...More data for this Ligand-Target Pair
Affinity DataKi: 3.00E+5nMAssay Description:Ki value against human carbonic anhydrase IIIMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+5nMAssay Description:Inhibitory constant against cytosolic human Carbonic anhydrase III using CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+5nMAssay Description:Inhibition of human cytosolic isozyme CA IIIMore data for this Ligand-Target Pair
Affinity DataKd: 4.60E+3nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as kinetic dissociation constant ...More data for this Ligand-Target Pair
Affinity DataKd: 4.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as observed dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 2.40E+4nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 3 (4 to 260 residues) expressed in Escherichia coli BL21 (DE3) assess...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+5nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 3 (4 to 260 residues) expressed in Escherichia coli BL21 (DE3) in pre...More data for this Ligand-Target Pair
Affinity DataIC50: 840nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 hydrolysis activity using 4-nitrophenyl acetate as substrate preincubated for 10 mins prior to s...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 phosphatase activity using 4-nitrophenyl phosphate as substrate preincubated for 10 mins prior t...More data for this Ligand-Target Pair
Affinity DataKd: 4.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 3 at pH7 and 37 degC by fluorescent thermal shift assayMore data for this Ligand-Target Pair